What is Apolipoprotein - A?
Apoprotein(a) [apo(a)] is a unique macromolecule that is synthesised at a high rate in man that have lost their ability for endogenous ascorbate production . When associated with low-density lipoprotein (LDL) to form lipoprotein(a) [LP(a)] it becomes a primary risk factor for cardiovascular disease (CVD) . Subsequently we identified powerful beneficial properties of apo(a) in the defence against the proliferation of various diseases. These properties include the stabilisation of the extracellular matrix, the interaction with the coagulation system, antioxidative defence, and inhibition of plasmin-induced proteolysis. Ascorbate deficiency is the metabolic condition where these defence mechanisms are required. Moreover, we identified prolonged periods of ascorbate deficiency during evolution as the life-threatening conditions that lead to the high production of apo(a).
APO - A.