What is Apolipoprotein - B?
Apolipoprotein b is the primary apolipoprotein of low-density lipoproteins (LDL or "bad cholesterol"), which is responsible for carrying cholesterol to tissues. While it is unclear exactly what functional role Apo b plays in LDL, it is the primary apolipoprotein component and is absolutely required for its formation. What is clear is that the Apo b on the LDL particle acts as a ligand for LDL receptors in various cells throughout the body (i.e. less formally, Apo b"unlocks" the doors to cells and thereby delivers cholesterol to them). Through a mechanism that is not fully understood, high levels of Apo b can lead to plaques that cause vascular disease (atherosclerosis), leading to heart disease. There is considerable evidence that levels of Apo b are a better indicator of heart disease risk than total cholesterol or LDL. However, primarily for historic reasons, cholesterol, and more specifically, LDL-cholesterol, remains the primary lipid test for the risk factor of atherosclerosis
APO - B.